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10.1016/s0014-2999(99)00486-0 54 KachlikD.BacaV.StinglJ

Systemic Administration There are two main approaches: Local injections : Targeting the injured tendon, ligament, or muscle for direct effect

It reduces inflammation in the gut and skin

Smoking impairs wound healing through vasoconstriction, reduced oxygen delivery, and impaired immune function

Concurrently, Th1/Th17 cells undergo aberrant activation, Tregs exhibit functional impairment, and B cells secrete autoantibodies, which form immune complexes that deposit in the synovium (115)

Endotoxins can introduce variability and confounding effects in in-vitro and laboratory experiments