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Adverse effects: Seek medical advice if you develop any unusual, severe, or persistent side effects or symptoms after taking vitamin B12 supplements

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This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases

The sham surgery group (Sham) serves as the control

That enzyme is NNMT, nicotinamide N-methyltransferase