However, body weight regulation is complex: it is dependent on appetite regulation, nutritional factors and eating behaviours, which includes biological and genetic mechanisms evidenced by heritability not only of modest effect size as in twin studies but also of epigenetic factors, and is not completely under personal control [53]
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57 Overwhelming mtROS levels lead to telomere shortening by generating single-strand breaks in telomeric regions, which may suggest a mechanism by which ROS-mediated cellular senescence regulates telomere health
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