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Nat Rev Cancer (2013) 13:23345

Mutations in exon 14 are the most common MET mutations found in NSCLC patients ( MET exon 14 mutations are point mutations, but indels, insertions, and deletions are also found ( Rearrangement of the anaplastic lymphoma kinase gene ( ALK ) has been identified in 5%6% of younger NSCLC patients ( ALK mutation develop drug resistance after taking drugs for a few years

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