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Mechanistically, NETderived histones bind to endothelial cell TLR2/TLR4 and trigger NFB and MAPKmediated upregulation of adhesion molecules (ICAM1, VCAM1, Eselectin), thereby promoting neutrophil and platelet tethering [81]

The mechanism is hypothesized to involve enhanced Schwann cell function and axonal sprouting, potentially via the growth factor pathways already implicated in its other activities

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Funct Plant Biol 30:955963 Zagorchev L, Seal CE, Kranner I, Odjakova MA (2013) Central role for thiols in plant tolerance to abiotic stress