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The FDA has indicated that it will begin enforcing the graphic warnings requirement in December 2025

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COPD was defined as the presence of the J43-J44 code (except J43.0) (ICD-10) and the prescription of COPD medication at least twice within 1 year

51,52 As more governments legislate for, or are moving toward, pack inserts, work is needed to understand how best to incorporate these within RYO pouches, what RYO specific inserts appear to work best, and the potential impacts of such inserts among this population