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Data on reducing smoking in people who did not quit showed that 36 percent of e-cigarette users halved the number of conventional cigarettes they smoked, compared with 28 percent of placebo users

Kidney damage: There have been reports of acute kidney injury in some individuals who use Spice, which can lead to long-term kidney damage or failure

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Moreover, the parallel induction of PGC1 and NRF2 target genes suggests a coordinated adaptation linking mitochondrial function to antioxidant defense