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Association Between Exclusive Pipe Smoking and Mortality From Cancer and Other Diseases - Journal of the National Cancer Institute , Volume 96, Issue 11, 2 June 2004, Pages 853861, Conclusion: Similar risk to cigar smoking Reducing Risks of Pipe and Cigar Smoking - Summary Notes from the lecture of Henri P

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This is consistent with the incentive-sensitization theory of addiction 4, 5 , which proposes that neutral stimuli can promote drug-seeking behaviour through association with drug effects, and that this is mediated through sensitization of particular brain systems, principally the ventral striatum