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Nearly half of cigarettes circulating in Australia are illegal and its driving a concerning spike in smoking

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The incidence of myocardial infarction increases in males and females and may lead to fatal coronary artery disease, as confirmed by epidemiological studies

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Subjects received open-label induction therapy at a dose based on their body weight (40 kg and 30) or who were non-responders (did not achieve a decrease in the PCDAI of 15 from baseline for 2 consecutive visits at least 2 weeks apart) were allowed to dose-escalate (i.e., switch from blinded every other week dosing to blinded every week dosing)