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Institutional Review Board Statement The study was conducted according to the guidelines of the Declaration of Helsinki, and the procedures involving animals were in accordance with the ethical standards of Nanjing First Hospital (protocol#: DWSY-1901438)

Vitamin B12 shot side effects Most people tolerate vitamin B12 injections well, but possible side effects include: Mild: soreness or redness at injection site, mild diarrhea, nausea, headache, itching Rare but serious: allergic reactions (rash, swelling, difficulty breathing), low potassium (hypokalemia), dizziness or heart rate changes Get emergency medical help if you have signs of an allergic reaction to Vitamin B12: hives

Sections were stained with haematoxyline and eosin

van Horssen J, Vos CM, Admiraal L, van Haastert ES, Montagne L, van der Valk P, et al