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Behavioural and physiological aspects of nicotine dependence As nicotine enters the body, nicotinic acetylcholine receptors (nAChRs) activate in the brain, releasing dopamine, which induces a pleasurable feeling

Hence, plasma levels of antipsychotics tend to increase if patients stop smoking, resulting in the appearance of dose-related side-effects such as extra-pyramidal symptoms (Desai Reference Desai, Seabolt and Jann2001)

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