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16 The term new drug is defined in section 321(p) of the FDCA, in part, as any drug that is not generally recognized as safe and effective, or has become so recognized, but has not been used to a material extent or for a material time

For example, in some Asian countries, smoking is more socially acceptable, and many people prefer to smoke smaller amounts at a time

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Lamin B1 maintains nuclear stability and regulates DNA replication and gene transcription [32]