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PMID: 37277863 Adv Sci (Weinh) Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib-Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency
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Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposis sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS malignancy consortium and IM862 study team
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It validates years of advocacy by clinical organizations arguing that compounding restrictions should be proportional to actual patient risk not applied uniformly across categories
Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig
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