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Therefore, an index like the S&P 500 now acts more like the information technology sector than it did a decade ago when the sector was less than 13% of the index, and certainly more than in 1990 when the sector had just a 6% weighting

The primary analysis will follow the intention-to-treat principle (ITT) [40] whereby all participants that drop out of the study or are otherwise lost-to-follow-up will be classified as still smoking

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