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Front Psychol

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We interpret the findings of the Million Hearts model to be both reflective of and perhaps augmenting an evolution in clinical practice toward quantitative ASCVD risk assessment

Environments acting during early embryogenesis (e.g., when global erasure and re-establishment of DNA methylation occur) may induce extensive, soma-wide modifications of DNA methylation, whereas environments acting later during life are more likely to induce less extensive, tissue-specific modifications of DNA methylation ( Figure 1 )

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