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This movement of charged particles is what we call electrical current

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Responsiveness of rat aorta and pulmonary artery to cGMP generators in the presence of thiol or heme oxidant

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The implication behind the original NCI bioassay was that if a chemical was found to cause neoplasms in treated animals, further studies would need to be designed and conducted to specifically determine parameters such as the mechanism of cancer induction, the nature of the doseresponse relationship, chemical metabolism, and target organ dosimetry