When cytoplasmic concentrations of neurotransmitters rise dangerously high, TAAR1 activates G-protein-dependent signaling pathways that recruit intracellular kinases, including protein kinase C (PKC) and calcium/calmodulin-dependent protein kinase II (CaMKII) (Underhill et al., 2020)
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When nicotine interacts with the brain in this way, it can cause a person to experience a slight, brief feeling of euphoria due to the release of endorphins
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