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The government of Chile, which introduced in 2013 a so-called 'Anti-Tobacco Law' to restrict the sale and consumption of cigarettes, now has a 75% tax on traditional cigarettes

The key distinction is the addition of menthol, which creates a cooling sensation and masks the smoke's harshness

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As of November 2019, the Centers for Disease Control and Prevention has confirmed 2,172 lung injury cases in the U.S., resulting in 42 deaths

Inclusion criteria were English-language publications involving e-cigarette aerosols, propylene glycol, glycerin, nicotine, or commonly used e-liquid flavoring agents in e-liquids, electronic nicotine delivery systems, that modulate the expression and/or function of inhibitory immune checkpoints