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The recently released 35th tobacco-related 2024 Surgeon Generals Report estimates that each year more than 490,000 deaths are attributable to cigarette smoking and exposure to secondhand tobacco smoke in the United States

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Furthermore, when mitochondrial depolarization caused mitochondrial protein import stress, NLRX1 recruited ribosome binding protein 1 (RRBP1) of the endoplasmic reticulum (ER) membrane to form the NLRX1/RRBP1 complex, which induced LC3 recruitment and lipidation, and consequently affected the formation of mitochondrial autophagosomes (Song et al., 2019)

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