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Reduced saliva production will cause bacteria to multiply in the mouth more quickly

Using a cell live (calcein AM) and cell death (propidium iodide) stain, the cytotoxic effect in 143B cells at a fixed concentration of 10 M Ru was visualized

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Visible skin brightening typically appears at 5-8 weeks with continued improvement over 3-6 months

Tsai G, Lane HY et al (2004)