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Each cigarette is made with organic tobacco and natural menthol, distinguishing it from other American Spirit options by offering a refreshing, cool taste

While some claim to be tobacco-free made with lab-created synthetic nicotine, or with nicotine that does not come from tobacco synthetic nicotine products still contain nicotine

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Subsequently, Gaussian normality of the AUC and C mean per PM class and tobacco product was tested, applying the DAgostino-Pearson test and a significance level of 0.05