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Since the 1950s, when the Federal Trade Commission sought to stop tobacco companies from portraying cigarettes as healthful, cigarette brands have suffered a slow and steady decline in advertising

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"Smoke 'em if you got 'em, boys."

Those refills (often called carts, short for cartridge) seem to be a prime suspect in the search for a cause of VAPIspecifically illicit cartridges sold on the black market

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[DOI] [PMC free article] [PubMed] [Google Scholar] [87].Ayala A, Muoz MF, Argelles S, Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal, Oxid Med Cell Longev, 2014 (2014) 360438