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Patients who have previously experienced a severe cutaneous adverse reaction to a medicine may develop SJS/TEN much more rapidly on rechallenge to the same drug or structurally related drugs [7], [12]

The H 2 S present in the initial homogenate was assessed by detection of S(CAM-TPP) 2 after protein precipitation in the first aliquot

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Indeed, the placebo fibrosis-improvement rate of 22% is a useful reminder of how noisy single biopsy-based fibrosis staging can be over less than a year, which is one reason regulators want multi-year outcome data before treating a fibrosis claim as established

This dual action triggered ICD, releasing damage-associated molecular patterns (DAMPs) that activated DCs and promoted CTL infiltration