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However, decreased responsiveness to VIM DBS by select body parts (possibly due to the somatotopic organization of the VIM nucleus) increased tolerance to VIM stimulation due to compensation or disease progression [176, 177], and the development of adverse side effects, such as dysarthia and dysphagia [174], in patients, has driven efforts to optimize DBS targeting

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A diferencia de otros compuestos, su estabilidad molecular le permite mantener su integridad en entornos gstricos y sistmicos, lo que lo convierte en un sujeto de estudio ideal para la investigacin de la regeneracin endgena