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This irreversible condition is commonly linked to smoking and falls under Chronic Obstructive Pulmonary Disease (COPD)

Centers for disease control and prevention (CDC)

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"The fun part of the first Hangover for me is, obviously the guys are really funny in it and they have chemistry and all that," notes Phillips, "but it's also a mystery and we didn't want to lose that investigative element, because that sort of keeps people leaning forward on their seats and involved in the story