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Food and Drug Administration) FDA meeting materials indicate FDA proposed that certain AOD-9604 forms not be included on the 503A bulks list at that time

While toxicity is rare, excessive intake of certain B vitamins (particularly B or B) from multiple sources could increase the risk of side effects (like niacin flush or peripheral neuropathy)

Is Vitamin B12 safe for long-term use

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For lower doses its more uncertain but there is a potential benefit to taking them with food