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4-Hydroxynonenal modulates blood-brain barrier permeability in vitro through changes in lipid composition and oxidative status of endothelial cells and astrocytes

In adult T-cell leukemia/lymphoma (ATLL), ART induced intracellular ROS- and iron-dependent cytotoxicity, which was partly inhibited by treatment with an iron chelator or ferroptosis inhibitor (Ishikawa et al., 2020)

A., Aiyelaagbe, O

doi:10.1016/j.cell.2013.05.039 5

Example calculations: 200mg vial + 2mL water = 100mg/mL (0.5mL injection delivers 50mg dose) 600mg vial + 3mL water = 200mg/mL (0.5mL injection delivers 100mg dose) 1000mg vial + 5mL water = 200mg/mL (1mL injection delivers 200mg dose) Most therapeutic protocols use 100200mg per injection, administered 23 times weekly

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