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While smoking is the best-characterized risk factor associated with BC 10,11,12,13,14 , whether the recent surge in E-cigarette use will similarly contribute to BC development remains to be established, although the presence of bladder carcinogens in the urine of E-cigarette users does support this possibility 29

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Although a Geek Bar Pulse contains about 800mg of nicotine in total, nicotine absorption differs from smoking

While the authors note that the overall certainty of evidence for long-term continuous abstinence remains low due to inconsistencies between studies, high attrition rates, reliance on self-reported data, and variability in sustained user engagement, the review underscores that the combination of pharmacotherapy and digital apps warrants further investigation in larger, higher-quality trials with longer follow-up and biochemical validation as a promising frontier in the quest to kick the cigarette habit