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However, it should be noted that the association between aldose reductase, osmotic stress, oxidative stress, while very strong in the rat because of the high aldose reductase levels, is not supported by the various clinical trials with aldose reductase inhibitors

Furthermore, fasting induces a metabolic shift from glucose to ketone utilization, providing neurons with a potent energy source that reduces mitochondrial stress and enhances bioenergetic stability [76]

An overview, 2021)

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Miyauchi, K., Urano, E., Yoshiyama, H

Some researchers report feeling better, recovering faster, and noticing improved resilience without obvious external changes