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But does this mean that you cant do anything about smoking or depression

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Thus, comprehensive tobacco control is urgently needed in LMICs, including full implementation of the World Heath Organization MPOWER measures (see Tobacco Control) and consideration of Endgame Strategies

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"So, the bottom line is that states are short-changing efforts to prevent and reduce tobacco use nationally

Using a second line drug should be considered only after using first-line or if there are contraindications to first-line