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For our COVID-19 analyses, we used a two-sided of 0.0025 (based on comparing four COVID-19 outcomes and five substance use exposures) and for the other infectious disease outcomes, a threshold of 0.00071 (based on comparing 14 FinnGen infectious respiratory diseases and five substance use exposures) as a heuristic that allows for follow-up analyses for a plausible number of findings

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More than 100,000 people die in the UK every year from a tobacco related illness, with 14 types of cancer caused by smoking

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Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis