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The studies were designed as open-label, randomized, crossover studies with 9 and 7 days of confinement for Study 1 and Study 2 respectively, were employed to assess nicotine PK, subjective effects, and physiological measures (Study 1 only) for 4 h after a 10-minute ad libitum ENDS product use

Differences between means of were compared by a 1-way ANOVA followed by the Newman-Keuls multiple comparison test