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Moreover, the ability of polyphenols to penetrate the BBB is compound specific and often suboptimal, necessitating advanced delivery strategies such as nanoformulations or prodrugs to enhance CNS targeting (Ramakrishna et al
The generalization of the skin wound healing therapy (Seiwerth et al., 1997
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Recruitment of liposomes as topical drug delivery systems would be promising due to their numerous advantages including enhanced skin penetration through the stratum corneum layer, skin moisturizing and restoring effects, controlled drug release, and biocompatibility and biodegradability properties (Rahimpour and Hamishehkar, 2012)