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These commonly include: Alterations in alertness: Such as drowsiness or, paradoxically, increased wakefulness

According to critics of the tobacco industry, the holes create a flexible dosing system that allows addicted smokers to maintain the tar and nicotine levels they crave while believing they are receiving lower, safer doses

For more on the FDAs premarket review process for e-cigarettes, see the Public Health Law Centers factsheet, Extensions and Epidemics: The FDAs Gatekeeping Authority for E-Cigarettes and see updates on the FDA decisions on their Tobacco Product Applications: Metrics & Reporting page as well as on their Tobacco Product Marketing Orders page

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Fletcher, William Younger