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Nicotine Analogs Covered: The ban extends to products containing nicotine analogs or synthetic nicotine compounds (like 6-methyl nicotine or Metatine) if they contribute to a characterizing flavor

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In 2016, Reynolds American marketed its Newport cigarettes with a tour featuring mobile Newport pleasure lounges at events and places popular with young adults, such as musical festivals, bars and convenience stores

Furthermore, in silico studies showed interaction of 7 nAChRs with RBDs of SARS-CoV-2 spike glycoproteins, indicating dysregulation of the nicotinic cholinergic system and leading to cytokine storm in COVID-19 patients [332, 333]