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None of the covariates had a statistically significant association with appeal

In addition, we provide a mechanistic understanding of how reward processing may be altered at the level of the VTA in response to chronic nicotine

Following the incident, major retail channels remained cautious toward e-cigarettes, limiting further channel expansion

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Finally, the sample size used here exceeds that of previous studies of the combined effects of nicotine and caffeine in regular users (eg, 9-19 participants) and nonusers of nicotine (eg, 10 participants), but may nonetheless have limited study sensitivity

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