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J Abnorm Psychol 117(2):467472 PMID:18489224 Zhang K, Liang H (2024) Causal impacts of smoking on pain conditions and the mediating pathways: a Mendelian randomization study

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They added these genes to tobacco plantswhich dont naturally produce baccatin IIIand found the plants readily pumped out the chemical at similar levels to yew tree needles