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For example, a 2009 study found that teens who used marijuana as well as alcohol suffered significantly less damage to the white matter in their brains

Another effect of nicotine is the reduction in cerebral glucose utilization: prolonged exposure to nicotine, whether from traditional or e-cigarettes, induces an increase in the expression of GLUT1 in the brain, leading to a reduction in glycolysis, which causes a condition of glucose deprivation that increases the risk of stroke and worsens ischemic damage [111]

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