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Murad IV, sultan of the Ottoman Empire, 162340, was among the first to attempt a smoking ban by claiming it was a threat to public morals and health

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Other investigations in more homogeneous, slightly older cohorts, such as the Whitehall II Cohort Study, 39 Honolulu-Asia Aging Study, 40 and the Doetinchem Cohort Study, 41 have also indicated that midlife and late-life smoking may contribute to poor late-life cognition, but these studies have focused on evaluating current exposure

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