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In the original mouse work it was described as well-tolerated, but that is the limit of the in-vivo safety evidence, and it is mouse-only

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Handling: Wear appropriate personal protective equipment (PPE) including gloves and safety eyewear

Experiments running for several weeks or months require a stable compound

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A recently published study found that rinsing with green tea reduced plaque-forming bacteria in the mouth just as well as a prescription mouthwash