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It is banned by WADA for competitive athletes

Nature Reviews Immunology , 9 (11), 799809

Pregnant or breastfeeding women should not use AOD-9604 due to lack of safety data in these populations

Some non-deficient folks may subjectively feel more energetic or in a better mood after getting stuck, but the shots probably dont confer any actual physiological benefit for them A B12 deficiency is difficult to diagnose

Those with the MTHFR genetic mutation, certain developmental delays in children, and other conditions linked to impaired methylation often find synthetic forms ineffective, making methylcobalamin injections vital

In winter there are the lowest temperatures and the region is usually cold, dry and very windy