10.1006/abbi.1997.0473
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This suggests that MZB and FoB depend on a different redox state and that the loss of GSH in FoB may induce MZB-like properties
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Results revealed a reduction in hepatic lipid accumulation and oxidative stress, hepatic fibrosis via modulation of -smooth muscle actin (SMA), peroxisome-activated receptor gamma (PPAR), and nuclear factor kappa B (Nf-B) expression ( Treatment of NAFLD With L-Carnitine Supplementation Since the effects of NAFLD are reversible, it is important to control the disease in its early stages ( 10 , vitamin E, vine tea polyphenol, cytoprotective agents (ursodeoxycholic acid), and insulin sensitizers (pioglitazone and metformin) ( L-carnitine, the only biologically active form of carnitine, has been one of the most widely studied molecules for the treatment of NAFLD
Consequently, the use of FSP1 inhibitors combined with ferroptosis-inducing therapies is recommended for treating KRAS-mutant cancers, including PDAC [77]
