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4.3 Protein-based NPs Protein-based NPs (PNPs) have emerged as a transformative strategy to counteract melanomas immunosuppressive TME, addressing key challenges such as immune evasion, defective antigen presentation, and impaired cytotoxic T cell activity ( Table 3 )

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Acknowledgements We thank the University of Maine Animal Facility staff for their assistance with animal care and handling, and the University of Maine Food Pilot Plant for their help with diet preparation