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2,3-Butanedione has been linked to a rare but severe lung disease called bronchiolitis obliterans, which is also known as popcorn lung, a term adapted when popcorn factory workers acquired the disease after being exposed to high levels of the vaporized substance

Treatment plans should be tailored to individual patients, taking into account each patients needs and preferences

Nat Genet 40(12):14071409 Amos CI et al (2010) A susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers

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Zhou: Writing original draft, Writing review & editing