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Ultrastructural alterations with phagocytic discoveries in blood vessels are also observed in these mice [72]

While the primary endpoint (cerebral glucose metabolism) was not met, these findings suggest injectable GLP-1s may be more effective than oral formulations

Syringes are inexpensive compared to the peptide

For patients who have exhausted conventional sleep interventions (sleep hygiene, CBT-I, conventional medications) and remain symptomatic, DSIP represents a speculative option with a plausible mechanism

Subjects immediately reported a feeling of sleep pressure, and total sleep time increased by 59% (median) within a 130-minute interval compared to placebo

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