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HTPs are also being used by people who have not previously smoked 15 , with adolescents being over twice as likely as adults to have tried one 16

Although they originate in different cells, experts group them together due to similarities in treatment and prognosis

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Deficiency of tetrahydrobiopterin, an essential cofactor for eNOS, has been shown to promote eNOS unpairing, which attenuates NO production and tends to enhance ROS production [75]