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the largest number (n = 882, 41%) were also current cigarette smokers, followed by former (n = 686, 31%) and never cigarette smokers (i.e., exclusive cigar, n = 600, 28%)

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Clinical trials analysing a class of cancer medication called small-molecule tyrosine kinase inhibitors, which targets a family of proteins that are mutated in many types of cancer, showed that never-smokers, individuals with adenocarcinoma, women and people with east Asian ancestry were more likely to respond well to the drugs than people with a history of smoking 2