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Moving from strong to medium, then eventually to low strength, is a common and effective path for long-term users

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Smoking or chewing tobacco does terrible things to your oral health

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This framework evaluates several key aspects: biological plausibility (i.e., whether the upstream and downstream events are mechanistically linked), the essentiality of key events (i.e., whether blocking an upstream KE prevents the occurrence of downstream events), empirical support (i.e., consistency with doseresponse, temporal, and incidence patterns), and overall coherence across studies (52)

The plants suspected of causing the deaths and illness were noted to be similar in appearance to Solanum mauritianum (wild tobacco) and initial prognostic advice was given to the owner on this basis