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Collectively, the evidence derived from both observational and mechanistic studies indicates a potential association between elevated triglyceride (TG) levels and depression, as systematically outlined in Table 1

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Multiple CVB variants have been shown to induce cell degeneration, pyknosis, reduction of islet identity genes, and decreased insulin content and secretion in primary human islets cultured in vitro or transplanted into diabetic NOD mice (141, 143)

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