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Many men report significant improvements in the following areas after cessation or nicotine withdrawal: Sleep Quality: Nicotine disrupts deep sleep, where most testosterone is produced

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Consistently, in Gpr15 +/+ mice, prolonged cigarette smoke exposure in the TNBS model led to aggravated colitis, as reflected by greater weight loss, elevated DAI, colon shortening, and worsened histological and endoscopic scores, accompanied by increased Gpr15 expression (Supplementary Fig